Clinical characteristics and prognosis of chronic obstructive pulmonary disease phenotype classified by high resolution computer tomography

Objective Chronic obstructive pulmonary disease (COPD) patients were divided into different phenotypes by high resolution computer tomography (HRCT) to investigate the clinical features and prognosis of different phenotype. Methods Ninety-three COPD patients were divided into three phenotype groups: A (n=51), E (n=18) and M (n=24) by HRCT, the differences of sex distribution, COPD exacerbations, erythrocyte sedimentation rate (ESR), blood gas analysis, and cumulative survival rate between the three groups were analyzed. Results (1)Femal distribution ratio was higher (χ2=8.60, 10.12, both P<0.05) and LAA scores was lower (χ2=20.90, 10.80, both P<0.05) in A phenotype than E and M phenotype.(2)ESR was higher in M phenotype than A phenotype (F=10.98, P<0.05). (3)Artery pressure of carbon dioxide as higher (F=7.80, 5.60, both P<0.05) and cumulative survival rate was lower in E phenotype than A and M phenotype (χ2=6.90, 6.74, both P<0.05). Conclusions To divide COPD according to HRCT, the clinical features and prognosis are different in different COPD phenotypes. Key words: Pulmonary disease, chronic obstructive; Phenotype; High resolution computed tomography