Enzyme‐Encapsulated DNA Hydrogel for Highly Efficient Electrochemical Sensing Glucose

Abstract An innovative bioetching photoelectrochemical (PEC) mode was developed by using enzyme‐encapsulated DNA hydrogel for high‐precision quantification of glucose, using In 2 O 3 −CdS nanocomposite as a photoactive matrix. In a proof‐of‐concept study, horseradish peroxidase and glucose oxidase were encapsulated in situ in DNA hydrogel to initiate enzymatic bioetching of CdS nanoparticles in the presence of target glucose. The bioetching reaction of CdS inhibits the electron transfer efficiency of In 2 O 3 and CdS, which causes a change in photocurrent intensity and thus provides a powerful bioetching PEC strategy with enzyme‐encapsulated DNA hydrogel.