微分脉冲伏安法
石墨烯
帕罗西汀
材料科学
磷钨酸
扫描电子显微镜
检出限
拉曼光谱
分析化学(期刊)
傅里叶变换红外光谱
电化学气体传感器
介电谱
化学
循环伏安法
核化学
电极
电化学
色谱法
纳米技术
化学工程
血清素
有机化学
物理化学
复合材料
工程类
催化作用
受体
物理
光学
生物化学
作者
Abbas Hassan Oghli,Ahmad Soleymanpour
标识
DOI:10.1016/j.msec.2019.110407
摘要
Paroxetine is an effective drug for the treatment of depression and stress which has been commonly used in recent years. Because of the widespread use and therapeutic effects of paroxetine, a rapid and sensitive method is needed to determine the trace concentration of paroxetine. Herein, an electrochemical sensor was constructed for the measurement of paroxetine using a modified pencil graphite electrode (PGE). Modification of the PGE was carried out by the reduced graphene oxide/phosphotungstic acid (rGO/PWA) by potentiostatic procedure at −1.2 V for 5 min in phosphate buffer solution with pH = 7.0. Surface morphology analyzing of the modified PGE was performed by scanning electron microscopy (SEM), Raman, XRD, FTIR and electrochemical impedance spectroscopy (EIS) techniques. The kinetic parameter of electron transfer coefficient (α) was calculated for the oxidation process of paroxetine at the modified PGE. Differential pulse voltammetry (DPV) was performed for the determination of PRX. The calibration graph exhibited linear characteristics in the range of 8.0 × 10−9–1.0 × 10−6 M of PRX concentration (R2 = 0.998). The relevant limit of detection was found to be 9.0 × 10−10 M. The modified PGE was successfully performed for the determination of PRX in paroxetine tablets and real samples such as human serum and urine.
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