Diastereoselective and enantioselective glyoxylate-ene reaction catalyzed by new class of binaphthol-derived titanium complex

Diastereo- and enantioselective carbonyl-ene reaction of glyoxylate (2) with trisubstituted olefins (3) catalyzed by chiral titanium complexes (1a), derived from 6,6′-dibromo-1,1′-bi-2-naphthol and diisopropoxytitanium dihalides, is found to provide syn-diastereomers exclusively along with a high level of enantioselectivity.