免疫系统
体内
药理学
脾细胞
刀豆蛋白A
脂多糖
腹腔注射
流式细胞术
刺激
免疫学
化学
传统医学
医学
生物
体外
生物化学
内分泌学
生物技术
作者
Yu Kang Chang,Jai Sing Yang,Jinghong Yang,Chang Lin Wu,Sun‐Yran Chang,Kaining Lu,Chao Lin Kuo,Te Chun Hsia,Jing Gung Chung
出处
期刊:PubMed
日期:2009-09-26
卷期号:23 (5): 755-9
被引量:4
摘要
Enhanced fruit and vegetable consumption is closely related to reduced cancer incidence as shown in epidemiological studies. Ganoderma lucidum, one of the most well-known traditional Chinese medicines, has been demonstrated to have pharmacological activities and antitumor effects, in Asian populations. However, the promotion of immune responses in normal BALB/c mice is unclear. In the present study, we investigated the immune responses of BALB/c mice after treatment with G. lucidum extract in vivo. The results demonstrated that G. lucidum extract was able to promote the proliferation of splenocytes under Concanavalin A or lipopolysaccharide stimulation. Compared with the control group, phagocytosis of macrophage was significantly enhanced by intraperitoneal administration of G. lucidum extract at both 3 and 6 mg/kg. Compared with the control group, natural killer cell activity was significantly enhanced by intraperitoneal administration of G. lucidum extract (6 mg/kg). Results of cytometric bead array and flow cytometry indicated that the expressions of interleukin-6 and interferon-gamma also increased (p<0.001) by treatment with G. lucidum extract (3 and 6 mg/kg). In conclusion, the findings of this study implied that G. lucidum extract was able to effectively promote immune responses in BALB/c mice.
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