Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients With Kawasaki Disease

医学 逻辑回归 川崎病 接收机工作特性 抗体 曲线下面积 内科学 科恩卡帕 卡帕 免疫学 胃肠病学 机器学习 语言学 哲学 动脉 计算机科学
作者
Tohru Kobayashi,Yoshinari Inoue,Kazuo Takeuchi,Yasunori Okada,Kazushi Tamura,Takeshi Tomomasa,Tomio Kobayashi,Akihiro Morikawa
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:113 (22): 2606-2612 被引量:747
标识
DOI:10.1161/circulationaha.105.592865
摘要

In the present study, we developed models to predict unresponsiveness to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD).We reviewed clinical records of 546 consecutive KD patients (development dataset) and 204 subsequent KD patients (validation dataset). All received IVIG for treatment of KD. IVIG nonresponders were defined by fever persisting beyond 24 hours or recrudescent fever associated with KD symptoms after an afebrile period. A 7-variable logistic model was constructed, including day of illness at initial treatment, age in months, percentage of white blood cells representing neutrophils, platelet count, and serum aspartate aminotransferase, sodium, and C-reactive protein, which generated an area under the receiver-operating-characteristics curve of 0.84 and 0.90 for the development and validation datasets, respectively. Using both datasets, the 7 variables were used to generate a simple scoring model that gave an area under the receiver-operating-characteristics curve of 0.85. For a cutoff of 0.15 or more in the logistic regression model and 4 points or more in the simple scoring model, sensitivity and specificity were 86% and 67% in the logistic model and 86% and 68% in the simple scoring model. The kappa statistic is 0.67, indicating good agreement between the logistic and simple scoring models.Our predictive models showed high sensitivity and specificity in identifying IVIG nonresponders among KD patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
sciences发布了新的文献求助10
1秒前
香蕉觅云应助学术小白采纳,获得10
3秒前
3秒前
3秒前
向xiang123发布了新的文献求助10
3秒前
天气预报员完成签到,获得积分10
4秒前
风中雨双发布了新的文献求助10
4秒前
勤奋的白桃完成签到,获得积分10
4秒前
5秒前
pp完成签到,获得积分10
5秒前
6秒前
6秒前
淡然的铭发布了新的文献求助30
7秒前
8秒前
Onetwothree完成签到 ,获得积分10
8秒前
8秒前
yunli发布了新的文献求助10
8秒前
高一完成签到,获得积分10
9秒前
9秒前
9秒前
张琳发布了新的文献求助10
9秒前
隐形曼青应助撒个人采纳,获得10
10秒前
小蘑菇应助111采纳,获得10
10秒前
10秒前
哈哈哈哈哈完成签到,获得积分10
10秒前
lzy发布了新的文献求助10
11秒前
CodeCraft应助缓冲间采纳,获得10
11秒前
Huay发布了新的文献求助20
11秒前
TowarDre4m完成签到,获得积分10
15秒前
科研通AI2S应助科研通管家采纳,获得10
17秒前
小蘑菇应助科研通管家采纳,获得10
17秒前
香蕉觅云应助洁净之柔采纳,获得10
17秒前
NexusExplorer应助科研通管家采纳,获得30
17秒前
王博士应助科研通管家采纳,获得30
17秒前
17秒前
17秒前
紧张的怀蝶完成签到,获得积分10
19秒前
19秒前
三黑猫应助俏皮新儿采纳,获得10
19秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3252389
求助须知:如何正确求助?哪些是违规求助? 2895233
关于积分的说明 8285379
捐赠科研通 2563884
什么是DOI,文献DOI怎么找? 1391979
科研通“疑难数据库(出版商)”最低求助积分说明 651992
邀请新用户注册赠送积分活动 629282