The integrative function of the subcortical brain structures in higher animals, realized partially via points of reinforcement and avoidance present in hypothalamic nuclei or via the hypothalamo-hypophysial system, suggest the special role these points play in the general and specific schemes of regulation of the nerve system. Stimulation of these points probably affects the brain structures by causing certain ascending effects, thus affects the animal's behavior during self-stimulation. The experimental approach described below is based on the brain itself as the stimulation source, thus allowing the investigation of an oriented effect on the hypothalamus on a similar source.