This study examines the effects of a community-based program designed to delay onset and reduce the frequency of alcohol and other drug (AOD) use among high-risk youths, ages 12 to 14, through strengthening family resilience. It is part of a larger five-year demonstration project funded by the Center for Substance Abuse Prevention (CSAP). The program was implemented in multiple church communities in rural, suburban, and inner-city settings. Program components of this study included parent or guardian and youth training, early intervention services, and follow-up case management services. The results show that the program produced positive direct effects on family resilience. The evaluation also found positive moderating effects on delayed onset of alcohol and other drug use and frequency of alcohol and other drug use among youths in the form of conditional relationships with changes in those family resilience factors that were targeted by the program.