加压器
生物
辅活化剂
转录因子
基因表达调控
计算生物学
细胞生物学
表观遗传学
遗传学
基因
抑制因子
作者
Michael G. Rosenfeld,Victoria V. Lunyak,Christopher K. Glass
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2006-06-01
卷期号:20 (11): 1405-1428
被引量:941
摘要
A decade of intensive investigation of coactivators and corepressors required for regulated actions of DNA-binding transcription factors has revealed a network of sequentially exchanged cofactor complexes that execute a series of enzymatic modifications required for regulated gene expression. These coregulator complexes possess “sensing” activities required for interpretation of multiple signaling pathways. In this review, we examine recent progress in understanding the functional consequences of “molecular sensor” and “molecular adaptor” actions of corepressor/coactivator complexes in integrating signal-dependent programs of transcriptional responses at the molecular level. This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.
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