塔塔盒子
塔塔结合蛋白
发起人
转录因子ⅡA
塔塔盒结合蛋白
转录因子ⅡD
生物
抄写(语言学)
分子生物学
RNA聚合酶Ⅱ
细胞生物学
化学
生物化学
基因
基因表达
哲学
语言学
作者
Làszlò Tora,H. Th. Marc Timmers
标识
DOI:10.1016/j.tibs.2010.01.007
摘要
Early work established the TATA box as the predominant DNA element of core promoters which directed accurate transcription initiation by RNA polymerase II. This element is recognized by TATA-binding protein (TBP), the central DNA-binding subunit of TFIID. In vitro binding and structural experiments indicate that TBP has a strong preference for TATA and induces severe DNA bending. Recent in vivo studies in Saccharomyces cerevisiae indicate that TBP turnover is higher at TATA-containing than at TATA-less promoters; this turnover seems to be regulated by NC2 and Mot1p. We propose that bending of TATA by TBP acts in synergy with NC2 and Mot1p to release TBP more rapidly from TATA promoters in vivo, thus providing a rationale for the predominance of TATA boxes in highly regulated promoters versus constitutively active TATA-less promoters.
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