Monocyte subsets and monocyte-platelet aggregates: implications in predicting septic mortality among surgical critical illness patients

Monocyte subsets and monocyte-platelet aggregates (MPAs) play important roles in inflammation.To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients.Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte-platelet aggregates were determined by flow cytometric analysis.Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality.This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.