内科学
内分泌学
醛固酮
血浆肾素活性
代谢性酸中毒
酸中毒
乳酸性酸中毒
乳酸
地塞米松
普萘洛尔
肾素-血管紧张素系统
化学
医学
生物
血压
细菌
遗传学
作者
Guido O. Pérez,David C. Kem,James R. Oster,Carlos A. Vaamonde
出处
期刊:PubMed
日期:1980-08-01
卷期号:96 (2): 371-8
被引量:14
摘要
Recent observations suggest that PA increases during acute metabolic acidosis. The pathophysiological mechanism(s) involved remains undefined. In the present study, anesthetized mongrel dogs were infused with lactic acid (10 mEq/kg body weight) for 3 hr. During acidosis there was no change in plasma potassium concentration, a tendency for an incrase in PRA, and significant increases in PC (as a marker for ACTH secretion) and PA. Other dogs were infused with lactic acid after prior treatment with dexamethasone and propranolol or with dexamethasone alone. Under these conditions, the development of acidosis was not associated with changes in PC, plasma potassium, PRA, or PA, suggesting that the stimulatory effect of acidosis on PA is not a direct one but is mediated by concomitant increases in ACTH and/or PRA.
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