Patterns of Relapse after Definitive Chemoradiotherapy in Stage II/III (Non-T4) Esophageal Squamous Cell Carcinoma

医学 食管胃十二指肠镜检查 胃肠病学 放化疗 食管癌 内科学 阶段(地层学) 食管鳞状细胞癌 癌症 内窥镜检查 生物 古生物学
作者
Kazuki Sudo,Ken Kato,Hiroki Kuwabara,Yusuke Sasaki,Naoki Takahashi,Hirokazu Shoji,Satoru Iwasa,Yoshitaka Honma,Natsuko Okita,Atsuo Takashima,Tetsuya Hamaguchi,Yasuhide Yamada,Yoshinori Ito,Jun Itami,Takahiro Fukuda,Kensei Tobinai,Narikazu Boku
出处
期刊:Oncology [Karger Publishers]
卷期号:94 (1): 47-54 被引量:14
标识
DOI:10.1159/000480515
摘要

The purpose of this study was to investigate the utility of surveillance after definitive chemoradiotherapy (dCRT) in patients with squamous cell carcinoma.Patients who underwent dCRT for stage II/III (excluding T4) esophageal squamous cell carcinoma were analyzed. First failures following complete response were classified into luminal relapse (LR), regional relapse (RR), distant metastasis (DM), new cancer diagnosed by esophagogastroduodenoscopy (NC-E), and new cancer other than NC-E (NC-O). We focused on LR, RR, and NC-E, and analyzed their frequency, timings and survival outcomes after local treatments.Among 302 patients treated with dCRT, 204 achieved complete response. The number of patients who recurred with LR, RR, DM, NC-E, and NC-O were 28 (14% of 204), 13 (6%), 39 (19%), 34 (17%), and 16 (8%). Ninety-three percent of LRs were diagnosed within 3 years after dCRT, and all RRs were diagnosed within 2 years. Annual odds of NC-E did not decrease over time. Twenty-three patients with LR, 6 with RR, and 32 with NC-E underwent local treatment, and their median overall survivals were 49.2, 19.5, and 108.9 months.Surveillance with esophagogastroduodenoscopy may be important in the first 3 years after dCRT to detect LR and to detect NC-E beyond 3 years.
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