自养
柠檬酸合酶
固碳
柠檬酸循环
生物化学
嗜热菌
一氧化碳脱氢酶
酶
辅因子
古细菌
生物
硫黄
化学
ATP柠檬酸裂解酶
ATP合酶
三羧酸
细菌
基因
一氧化碳
光合作用
遗传学
催化作用
有机化学
作者
Achim Mall,Jessica Sobotta,Claudia Huber,Carolin Tschirner,Stefanie Kowarschik,Katarina Bačnik,Mario Mergelsberg,Matthias Boll,Michael Hügler,Wolfgang Eisenreich,Ivan A. Berg
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-02-01
卷期号:359 (6375): 563-567
被引量:157
标识
DOI:10.1126/science.aao2410
摘要
Biological inorganic carbon fixation proceeds through a number of fundamentally different autotrophic pathways that are defined by specific key enzymatic reactions. Detection of the enzymatic genes in (meta)genomes is widely used to estimate the contribution of individual organisms or communities to primary production. Here we show that the sulfur-reducing anaerobic deltaproteobacterium Desulfurella acetivorans is capable of both acetate oxidation and autotrophic carbon fixation, with the tricarboxylic acid cycle operating either in the oxidative or reductive direction, respectively. Under autotrophic conditions, the enzyme citrate synthase cleaves citrate adenosine triphosphate independently into acetyl coenzyme A and oxaloacetate, a reaction that has been regarded as impossible under physiological conditions. Because this overlooked, energetically efficient carbon fixation pathway lacks key enzymes, it may function unnoticed in many organisms, making bioinformatical predictions difficult, if not impossible.
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