合理设计
光动力疗法
热稳定性
纳米技术
材料科学
化学稳定性
化学
组合化学
有机化学
作者
Qi Yin,Peng Zhao,Rongjian Sa,Guangcun Chen,Jian Lü,Tian‐Fu Liu,Rong Cao
标识
DOI:10.1002/anie.201800354
摘要
Abstract The low structural stability of hydrogen‐bonded organic frameworks (HOFs) is a thorny issue retarding the development of HOFs. A rational design approach is now proposed for construction of a stable HOF. The resultant HOF (PFC‐1) exhibits high surface area of 2122 m 2 g −1 and excellent chemical stability (intact in concentrated HCl for at least 117 days). A new method of acid‐assisted crystalline redemption is used to readily cure the thermal damage to PFC‐1. With periodic integration of photoactive pyrene in the robust framework, PFC‐1 can efficiently encapsulate Doxorubicin (Doxo) for synergistic chemo‐photodynamic therapy, showing comparable therapeutic efficacy with the commercial Doxo yet considerably lower cytotoxicity. This work demonstrates the notorious stability issue of HOFs can be properly addressed through rational design, paving a way to develop robust HOFs and offering promising application perspectives.
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