化学
苯乙烯
催化作用
亲核细胞
铜
格式化
激进的
药物化学
羰基化
桂皮酸盐类
有机化学
烯烃
共聚物
一氧化碳
聚合物
作者
Balázs Budai,Alexandre Leclair,Qian Wang,Jieping Zhu
标识
DOI:10.1002/anie.201904263
摘要
Abstract Reported here is a copper‐catalyzed 1,2‐methoxy methoxycarbonylation of alkenes by an unprecedented use of methyl formate as a source of both the methoxy and the methoxycarbonyl groups. This reaction transforms styrene and its derivatives into value‐added β‐methoxy alkanoates and cinnamates, as well as medicinally important five‐membered heterocycles, such as functionalized tetrahydrofurans, γ‐lactones, and pyrrolidines. A ternary β‐diketiminato‐Cu I ‐styrene complex, fully characterized by NMR spectroscopy and X‐ray crystallographic analysis, is capable of catalyzing the same transformation. These findings suggest that pre‐coordination of electron‐rich alkenes to copper might play an important role in accelerating the addition of nucleophilic radicals to electron‐rich alkenes, and could have general implications in the design of novel radical‐based transformations.
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