肿瘤缺氧
缺氧(环境)
肿瘤微环境
光动力疗法
医学
充氧
肺癌
癌症
氧气
癌症研究
放射治疗
化学
病理
内科学
有机化学
作者
Xuejiao Song,Liangzhu Feng,Chao Liang,Kai Yang,Zhuang Liu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2016-09-13
卷期号:16 (10): 6145-6153
被引量:527
标识
DOI:10.1021/acs.nanolett.6b02365
摘要
Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen is needed in the process of cancer cell destruction. Herein, taking advantages of the great biocompatibility and high oxygen dissolving ability of perfluorocarbon (PFC), we develop an innovative strategy to modulate the tumor hypoxic microenvironment using nano-PFC as an oxygen shuttle for ultrasound triggered tumor-specific delivery of oxygen. In our experiment, nanodroplets of PFC stabilized by albumin are intravenously injected into tumor-bearing mice under hyperoxic breathing. With a low-power clinically adapted ultrasound transducer applied on their tumor, PFC nanodroplets that adsorb oxygen in the lung would rapidly release oxygen in the tumor under ultrasound stimulation, and then circulate back into the lung for reoxygenation. Such repeated cycles would result in dramatically enhanced tumor oxygenation and thus remarkably improved therapeutic outcomes in both PDT and RT treatment of tumors. Importantly, our strategy may be applied for different types of tumor models. Hence, this work presents a simple strategy to promote tumor oxygenation with great efficiency using agents and instruments readily available in the clinic, so as to overcome the hypoxia-associated resistance in cancer treatment.
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