Variability of lysozyme and lactoferrin bioactive protein concentrations in equine milk in relation to LYZ and LTF gene polymorphisms and expression

溶菌酶 乳铁蛋白 哺乳期 繁殖 生物 单核苷酸多态性 基因 食品科学 动物科学 遗传学 基因型 古生物学 怀孕
作者
J. Cieślak,Lukasz Wodas,Alicja Borowska,Jan Sadoch,Piotr Pawlak,Kamila Puppel,Beata Kuczyńska,Mariusz Mackowski
出处
期刊:Journal of the Science of Food and Agriculture [Wiley]
卷期号:97 (7): 2174-2181 被引量:13
标识
DOI:10.1002/jsfa.8026
摘要

Equine milk is considered to be an interesting product for human nutrition, mainly owing to its low allergenicity and significant amounts of bioactive proteins, including lysozyme (LYZ) and lactoferrin (LTF). The present study assessed the effect of genetic factors on LYZ and LTF concentration variability in mare's milk.Significant effects of horse breed and lactation stage on milk LYZ and LTF contents were observed. The highest level of LTF and the lowest concentration of LYZ were recorded for the Polish Warmblood Horse breed. The highest amounts of both proteins were found for the earliest investigated time point of lactation (5th week). Altogether 13 (nine novel) polymorphisms were found in the 5'-flanking regions of both genes, but they showed no significant relationship with milk LYZ and LTF contents. Several associations were found between selected SNPs and the LYZ gene relative transcript level.While the present study indicated the existence of intra- and interbreed variability of LYZ and LTF contents in mare's milk, this variation is rather unrelated to the 5'-flanking variants of genes encoding both proteins. This study is a good introduction for broader investigations focused on the genetic background for variability of bioactive protein contents in mare's milk. © 2016 Society of Chemical Industry.
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