[Analysis of risk factors for postsurgical gastroparesis syndrome (PGS) after operation for gastric cancer].

Objective: To investigate the risk factors for postsurgical gastroparesis syndrome (PGS) after surgery for stomach cancer. Methods: A total of 684 patients with gastric cancer who underwent surgery for stomach cancer from Jan. 1, 2010 to Dec. 31, 2014 in Tai'an Tumor Prevention and Treatment Hospital, including 475 males and 209 females, with an average age of 59.9 years were identified and included in this study. There were 206 cases of gastric cardia and gastric fundus cancers and 478 cases of gastric antrum cancer. 206 cases underwent proximal radical subtotal gastrectomy and D2 lymph node dissection, 478 distal radical subtotal gastrectomy, 206 residual esophagogastric anastomosis, 311 Billroth-Ⅰ anastomosis, 99 Billroth-Ⅱ anastomosis, and 68 Billroth-Ⅱ plus Roux-en-y anastomosis. The incidence and risk factors of PGS were analyzed. Results: All of the 684 patients were successfully operated.Among them, 48 (7.0%)encountered PGS. The univariate analysis showed that age, smoking index, alcohol consumption index, HP infection, scores of anxiety, preoperative albumin level, preoperative pyloric obstruction, site of resection, mode of anastomosis, whether to preserve the vagus nerve trunk, perioperative blood glucose level, abdominal cavity infection, and usage of postoperative analgesia pump were related to the occurrence of PGS (P<0.05 for all), while sex, hypertension, diabetes, perioperative hemoglobin level, perioperative electrolyte imbalance, operation duration, intraoperative blood loss, size of gastric remnant and number of dissected lymph nodes were not significantly related to the occurrence of PGS(P>0.05 for all). The multivariate binary logistic regression analysis showed that age, HP infection, scores of anxiety, perioperative albumin level, preoperative pyloric obstruction, site of resection, mode of anastomosis, whether to preserve the vagus nerve trunk, perioperative blood glucose level and abdominal cavity infection were risk factors for PGS (P<0.05 for all); while the age (<67 years old), perioperative albumin level (>35 g/L) and preservation of the vagus nerve trunk were protective factors of PGS (P<0.05 for all). Conclusions: The occurrence of PGS is affected by many factors. Detailed evaluation of patients'symptoms and physical signs before operation and rectifying and eliminating risk factors are important to prevent and reduce the occurrence of PGS in patients with gastric cancer.目的： 探讨影响胃癌术后胃瘫(PGS)发生的危险因素。 方法： 选取2010年1月1日至2014年12月31日间行胃癌手术患者684例，其中男475例，女209例，平均年龄59.9岁。贲门及胃底癌206例，胃窦癌478例。近端根治性胃大部切除＋D2淋巴结清扫术206例，远端根治性胃大部切除术＋D2淋巴结清扫术478例。食管残胃吻合术206例，毕Ⅰ式吻合术311例，毕Ⅱ式吻合术99例，毕Ⅱ＋Roux－en－y式吻合术68例。分析PGS的发生情况及其危险因素。 结果： 684例患者均顺利完成手术，发生PGS 48例，发生率为7.0%。单因素分析显示，年龄、吸烟指数、饮酒指数、幽门螺杆菌(HP)感染情况、焦虑评分、围手术期白蛋白水平、术前梗阻情况、切除位置、吻合方式、是否保留迷走神经干、围手术期血糖水平、腹腔感染情况和术后使用镇痛泵情况与PGS的发生有关(均P<0.05)，而性别、高血压、糖尿病、围手术期血红蛋白水平、围手术期电解质紊乱情况、手术时间、术中出血量、残胃大小和淋巴结清扫数目与PGS的发生无关(均P>0.05)。多因素分析显示，年龄、HP感染情况、焦虑评分、围手术期白蛋白水平、术前梗阻情况、切除位置、吻合方式、是否保留迷走神经干、围手术期血糖水平和腹腔感染情况是PGS发生的危险因素(均P<0.05)，年龄<67岁、围手术期白蛋白>35 g/L和保留迷走神经干是PGS发生的保护性因素。 结论： 多种因素与PGS的发生有关，术前应详细评估患者的症状和体征，及时纠正和消除导致PGS的危险因素，以预防和减少胃癌患者PGS的发生。.