分子印迹聚合物
检出限
化学
分子印迹
乙二胺
聚合物
荧光
碳纤维
核化学
柠檬酸
选择性
色谱法
有机化学
无机化学
材料科学
复合数
物理
复合材料
催化作用
量子力学
作者
Yunyan Ren,Zhefeng Fan
出处
期刊:Food Chemistry
[Elsevier]
日期:2023-03-02
卷期号:416: 135792-135792
被引量:36
标识
DOI:10.1016/j.foodchem.2023.135792
摘要
Tobramycin (TOB) plays a considerable role in combating milk spoilage and preventing disease in dairy cows. However, overuse of TOB can lead to nephrotoxicity, ototoxicity, neuromuscular blockade, and hypersensitivity reactions. Here, nitrogen-doped carbon dots (N-CDs) were prepared with ethylenediamine and citric acid, then molecularly imprinted layers were obtained by imprinting of surface on the N-CDs to prepare Nitrogen-doped carbon dot-based molecularly imprinted polymers (N-CDs@MIPs). The fluorescence emission spectrum of this probe showed a linear enhancement with the TOB concentration in the 1-12 μM. Meanwhile, a detection limit of 99.2 nM was obtained. This probe was not affected by the structural analogs of the TOB and can show high sensitivity and selectivity compared to non-imprinted polymers (N-CDs@NIPs). Therefore, it can be successfully used for the trace analysis of TOB in milk with advantages over other reported techniques such as liquid chromatography coupled with tandem mass spectrometry or various aptamer sensors.
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