葛根
洛巴塔
葛根素
微泡
巨噬细胞
巨噬细胞极化
炎症
免疫系统
促炎细胞因子
化学
传统医学
细胞生物学
生物
免疫学
医学
生物化学
小RNA
体外
替代医学
病理
基因
作者
Jiaqi Wu,Xiaoyu Ma,Yi Lu,Tao Zhang,Zuoqin Du,Jin Xu,Jingcan You,Ni Chen,Xin Deng,Jianbo Wu
出处
期刊:Molecules
[MDPI AG]
日期:2022-11-24
卷期号:27 (23): 8184-8184
被引量:18
标识
DOI:10.3390/molecules27238184
摘要
Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of P. lobata-derived exosomes (Exos) in isolated mouse macrophages. Our results show that P. lobata-derived Exos shift M1 macrophages toward the M2. These data present that P. lobata and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of P. lobata as novel an anti-inflammatory therapeutic biomaterial.
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