Effect of hematuria on the kidney disease progression in IgA nephropathy patients with mild proteinuria and well-preserved renal function

蛋白尿 肾功能 医学 肾病 泌尿科 血压 肾活检 肾脏疾病 胃肠病学 内科学 尿 肌酐 镜下血尿 内分泌学 糖尿病
作者
Youxia Liu,Hongshan Chen,He Wang,Zhao Li,Hongfen Li,Fanghao Wang,Junya Jia,Dong Li,Tiekun Yan
出处
期刊:International Immunopharmacology [Elsevier BV]
卷期号:122: 110635-110635 被引量:1
标识
DOI:10.1016/j.intimp.2023.110635
摘要

To investigate whether hematuria is a risk factor in IgA nephropathy (IgAN) patients with mild proteinuria and well-preserved renal function.This retrospective study included a total of 63 IgAN patients, with complete clinical data available for 50 patients. Hematuria assessment was conducted using two methods: 1) an automated method using a urine particle analyzer, and 2) a manual method performed by a skilled examiner to examine microscopic urine sediment.The results of hematuria measurement using both automated and manual methods showed a strong linear correlation (r = 0.78, P < 0.001). In IgAN patients, those with high urinary red blood cell count (U-RBCs) exhibited higher serum IgA levels compared to patients with low U-RBCs. Additionally, patients with crescent formation had higher levels of proteinuria compared to those without crescents. Patients who received immunosuppressive treatment displayed higher levels of systolic blood pressure (SBP) and mean arterial pressure (MAP), as well as lower levels of serum hemoglobin and albumin. They also had a higher prevalence of T1 lesions compared to patients who did not undergo immunosuppression. Furthermore, among patients with crescent formation, those who received immunosuppressive agents exhibited higher levels of SBP, diastolic blood pressure (DBP), MAP, and U-RBCs, as well as lower levels of albumin and proteinuria at the time of renal biopsy. No composite kidney endpoint events were observed in these groups of patients. The U-RBCs level was not identified as a risk factor influencing the decline of estimated glomerular filtration rate (eGFR) in IgAN.The presence of hematuria at the time of biopsy was not found to be associated with kidney disease progression in IgAN patients who had mild proteinuria and well-preserved renal function. This suggests that it is possible that these patients may not derive significant benefits from immunosuppressive therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
善良天抒完成签到 ,获得积分10
刚刚
鲸落发布了新的文献求助30
3秒前
葳葳完成签到,获得积分10
5秒前
sl发布了新的文献求助10
8秒前
8秒前
sanqian911完成签到,获得积分10
9秒前
昏睡的蟠桃应助liars采纳,获得150
10秒前
斯文败类应助荒野风采纳,获得10
10秒前
10秒前
hrzmlily完成签到,获得积分10
12秒前
顽主完成签到,获得积分10
13秒前
义气访曼完成签到 ,获得积分10
14秒前
时尚战斗机完成签到,获得积分10
14秒前
16秒前
亦玉完成签到,获得积分10
16秒前
Philadelphus完成签到,获得积分20
18秒前
18秒前
wsh完成签到 ,获得积分10
19秒前
luyue9406完成签到,获得积分10
19秒前
luochen完成签到,获得积分10
19秒前
酷波er应助奶黄包采纳,获得10
20秒前
ROMANTIC完成签到 ,获得积分10
20秒前
Hancock完成签到 ,获得积分10
21秒前
luyue9406发布了新的文献求助10
22秒前
Akim应助小王采纳,获得10
22秒前
甜蜜的楷瑞应助zqfxc采纳,获得10
24秒前
Hello应助花雨落123采纳,获得10
26秒前
27秒前
28秒前
柚仝完成签到 ,获得积分10
28秒前
贾明灵完成签到,获得积分10
28秒前
未来学术司马懿应助LIUYONG采纳,获得10
29秒前
Dops完成签到,获得积分10
31秒前
票子发布了新的文献求助10
32秒前
晚风完成签到 ,获得积分10
32秒前
坚强莺发布了新的文献求助10
32秒前
无奈曼云完成签到,获得积分10
33秒前
不会吹口哨完成签到,获得积分10
33秒前
易槐完成签到,获得积分10
34秒前
情怀应助和谐的梦蕊采纳,获得10
34秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029