Three-dimensional fluorinated covalent organic frameworks coated capillary for the separation of fluoroquinolones by capillary electrochromatography

毛细管电色谱 化学 毛细管作用 色谱法 共价键 毛细管电泳 离子液体 电色谱法 分辨率(逻辑) 分析化学(期刊) 有机化学 材料科学 复合材料 人工智能 计算机科学 催化作用
作者
Han Yin,Ziyi Zhen,Weijie Ning,Lu Zhang,Yuhong Xiang,Nengsheng Ye
出处
期刊:Journal of Chromatography A [Elsevier BV]
卷期号:1706: 464234-464234 被引量:10
标识
DOI:10.1016/j.chroma.2023.464234
摘要

In this work, a three-dimensional fluorinated covalent organic frameworks (3D FCOFs) JUC-515 was synthesized from tetra(4-aminophenyl)methane (TAM) and 2,3,5,6-tetrafluoroterephthalol (TFA) by an ionic liquid method. JUC-515 was introduced into the capillary column and bonded to the inner wall of the capillary column by chemical bonding. Through a variety of characterization results, JUC-515 was successfully synthesized and introduced into the capillary column. The effects of buffer solution concentration, organic additive content and pH of the buffer solution on the separation of fluoroquinolones (FQs) were investigated in detail. The JUC-515-coated capillary column showed good resolution (>1.5) and reproducibility. The relative standard deviations (RSDs) of the retention time for intraday, interday, column-to-column and interbatch precision were less than 0.88%, 2.45%, 2.74% and 3.32%, respectively. The RSDs of the peak area for intraday, interday, column-to-column and interbatch precision were less than 3.79%, 4.31%, 3.33% and 5.62%, respectively. The JUC-515-coated capillary column could be used no less than 150 times. The results showed that the JUC-515-coated capillary column had good separation performance. In addition, by separating fluorinated β-phenylalanine analogs, β-phenylalanine and trifluoromethyl β-phenylalanine analogs, the separation mechanism based on fluorine interactions was discussed. In conclusion, JUC-515 had good potential as a stationary phase for capillary electrochromatography.
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