人体皮肤
一氧化氮
伤口愈合
一氧化氮合酶
药理学
医学
纳米技术
化学
免疫学
生物
材料科学
遗传学
内分泌学
作者
Amedea B. Seabra,Joana C. Pieretti,Bianca de Melo Santana,Manuel Horue,Gonzalo Tortella,Guillermo R. Castro
标识
DOI:10.1016/j.ijpharm.2022.122465
摘要
Nitric oxide (NO) is an important endogenous molecule that plays several roles in biological systems. NO is synthesized in human skin by three isoforms of nitric oxide synthase (NOS) and, depending on the produced NO concentration, it can actuate in wound healing, dermal vasodilation, or skin defense against different pathogens, for example. Besides being endogenously produced, NO-based pharmacological formulations have been developed for dermatological applications targeting diverse pathologies such as bacterial infection, wound healing, leishmaniasis, and even esthetic issues such as acne and skin aging. Recent strategies focus mainly on developing smart NO-releasing nanomaterials/biomaterials, as they enable a sustained and targeted NO release, promoting an improved therapeutic effect. This review aims to overview and discuss the main mechanisms of NO in human skin, the recent progress in the field of dermatological formulations containing NO, and their application in several skin diseases, highlighting promising advances and future perspectives in the field.
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