化学
卡宾
酰化
催化作用
分子内力
组合化学
有机化学
立体化学
作者
Rong Zeng,Chuan Xie,Jin‐Dun Xing,Hai-Yu Dai,Mei-Hao He,Peng‐Shuai Xu,Qi‐Chun Yang,Bo Han,Jun‐Long Li
出处
期刊:Tetrahedron
[Elsevier]
日期:2023-02-01
卷期号:132: 133239-133239
被引量:5
标识
DOI:10.1016/j.tet.2022.133239
摘要
Available online A general and efficient method for constructing alkenyl-substituted isoquinolinones through N-heterocyclic carbene catalysis was described. The functionalization of benzamides with various enals proceeds smoothly through an N-center radical-mediated remote C (sp3)–H acylation and a cascade intramolecular hemiacetalization process. The newly designed thiazolium NHCs, exhibiting superior catalytic efficacy to activate the challenging enal substrates, is key to the success of this chemistry. This catalytic protocol further expands the generality of N-heterocyclic carbene radical catalysis.
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