Role of mechanoregulation in mast cell-mediated immune inflammation of the smooth muscle in the pathophysiology of esophageal motility disorders

医学 免疫系统 炎症 肌肉肥大 病理生理学 内科学 免疫学
作者
Raj K. Goyal,Satish Rattan
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology [American Physiological Society]
卷期号:326 (4): G398-G410 被引量:1
标识
DOI:10.1152/ajpgi.00258.2023
摘要

Major esophageal disorders involve obstructive transport of bolus to the stomach, causing symptoms of dysphagia and impaired clearing of the refluxed gastric contents. These may occur due to mechanical constriction of the esophageal lumen or loss of relaxation associated with deglutitive inhibition, as in achalasia-like disorders. Recently, immune inflammation has been identified as an important cause of esophageal strictures and the loss of inhibitory neurotransmission. These disorders are also associated with smooth muscle hypertrophy and hypercontractility, whose cause is unknown. This review investigated immune inflammation in the causation of smooth muscle changes in obstructive esophageal bolus transport. Findings suggest that smooth muscle hypertrophy occurs above the obstruction and is due to mechanical stress on the smooth muscles. The mechanostressed smooth muscles release cytokines and other molecules that may recruit and microlocalize mast cells to smooth muscle bundles, so that their products may have a close bidirectional effect on each other. Acting in a paracrine fashion, the inflammatory cytokines induce genetic and epigenetic changes in the smooth muscles, leading to smooth muscle hypercontractility, hypertrophy, and impaired relaxation. These changes may worsen difficulty in the esophageal transport. Immune processes differ in the first phase of obstructive bolus transport, and the second phase of muscle hypertrophy and hypercontractility. Moreover, changes in the type of mechanical stress may change immune response and effect on smooth muscles. Understanding immune signaling in causes of obstructive bolus transport, type of mechanical stress, and associated smooth muscle changes may help pathophysiology-based prevention and targeted treatment of esophageal motility disorders.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
感动黄豆发布了新的文献求助10
2秒前
李爱国应助故意的靳采纳,获得50
3秒前
研友_ngkyGn应助Akin采纳,获得10
3秒前
4秒前
双楠应助sunshine采纳,获得10
5秒前
胡航航完成签到,获得积分10
6秒前
hp发布了新的文献求助30
8秒前
yyauthor完成签到,获得积分10
8秒前
Quinna发布了新的文献求助10
10秒前
11秒前
14秒前
量子星尘发布了新的文献求助10
15秒前
cathy-w完成签到,获得积分0
16秒前
Sunnyside发布了新的文献求助10
16秒前
wenxiansci完成签到,获得积分0
17秒前
17秒前
19秒前
嗯嗯完成签到,获得积分10
20秒前
Zsir完成签到,获得积分10
20秒前
完美世界应助酷酷的友灵采纳,获得10
21秒前
英姑应助十九岁的时差采纳,获得10
24秒前
25秒前
ableyy完成签到,获得积分10
25秒前
25秒前
hhhblabla应助等待的花生采纳,获得10
26秒前
寒冷的小chao关注了科研通微信公众号
26秒前
28秒前
李李完成签到 ,获得积分10
28秒前
28秒前
lucy_zi发布了新的文献求助10
30秒前
闪闪w完成签到,获得积分10
31秒前
欣喜沛芹发布了新的文献求助10
32秒前
潇湘雪月发布了新的文献求助10
33秒前
33秒前
完美世界应助Bressanone采纳,获得10
34秒前
37秒前
徐哈哈发布了新的文献求助10
39秒前
41秒前
42秒前
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136