Surface‐Engineered Nanomaterials for Optical Array Based Sensing

Abstract Array based sensing governed by optical methods provides fast and economic way for detection of wide variety of analytes where the ideality of detection processes depends on the sensor element‘s versatile mode of interaction with multiple analytes in an unbiased manner. This can be achieved by either the receptor unit having multiple recognition moiety, or their surface property should possess tuning ability upon fabrication called surface engineering. Nanomaterials have a high surface to volume ratio, making them viable candidates for molecule recognition through surface adsorption phenomena, which makes it ideal to meet the above requirements. Most crucially, by engineering a nanomaterial's surface, one may produce cross‐reactive responses for a variety of analytes while focusing solely on a single nanomaterial. Depending on the nature of receptor elements, in the last decade the array‐based sensing has been considering as multimodal detection platform which operates through various pathway including single channel, multichannel, binding and indicator displacement assay, sequential ON‐OFF sensing, enzyme amplified and nanozyme based sensing etc. In this review we will deliver the working principle for Array‐based sensing by using various nanomaterials like nanoparticles, nanosheets, nanodots and self‐assembled nanomaterials and their surface functionality for suitable molecular recognition.