Data from Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer

前列腺癌 癌症 婚姻状况 前列腺 癌症登记处 肿瘤科 医学 人口学 老年学 妇科 内科学 社会学 人口
作者
Naiyu Chen,Colleen B. McGrath,Caroline I. Ericsson,Jane B. Vaselkiv,Emily M. Rencsok,Konrad H. Stopsack,Harold E. Guard,Karen A. Autio,Dana E. Rathkopf,Deborah Enting,Rhonda L. Bitting,Joaquín Mateo,Charles W. Githiaka,Kim N.,Heather H. Cheng,Ian D. Davis,Simon Anderson,Simone Badal,Anders Bjartell,Kjell M. Russnes,Elisabeth I. Heath,Mark M. Pomerantz,John C. Henegan,Terry Hyslop,Emilio Esteban,Aurelius Omlin,Ray McDermott,André P. Fay,Ademola Popoola,Camille Ragin,Joel Nowak,Travis Gerke,Philip W. Kantoff,Daniel J. George,Kathryn L. Penney,Lorelei A. Mucci
标识
DOI:10.1158/1055-9965.c.7100130.v1
摘要

<div>AbstractBackground:<p>Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).</p>Methods:<p>IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).</p>Results:<p>We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02–2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22–2.94).</p>Conclusions:<p>Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.</p>Impact:<p>This research highlighted the importance of social support in OS within this vulnerable population.</p></div>

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