聚合免疫球蛋白受体
分泌成分
免疫球蛋白A
J链
分泌性IgA
免疫系统
免疫球蛋白E
抗体
受体
粘膜免疫
免疫球蛋白G
免疫
化学
生物
免疫学
生物化学
出处
期刊:FEBS Journal
[Wiley]
日期:2024-02-08
卷期号:291 (16): 3597-3603
被引量:1
摘要
Immunoglobulin A (IgA) plays a crucial role in the human immune system, particularly in mucosal immunity. IgA antibodies that target the mucosal surface are made up of two to five IgA monomers linked together by the joining chain, forming polymeric molecules. These IgA polymers are transported across mucosal epithelial cells by the polymeric immunoglobulin receptor pIgR, resulting in the formation of secretory IgA (SIgA). This review aims to explore recent advancements in our molecular understanding of IgA, with a specific focus on SIgA, and the interaction between IgA and pathogen molecules.
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