化学选择性
化学
合成子
腙
亲核细胞
组合化学
选择性
亚膦
立体化学
药物化学
有机化学
催化作用
作者
Xin Wang,Dongping Chen,Wenpeng Wang,Chunhong Yang,Ming Li,Wenbo Xu,Zheng‐Jun Quan,Zheng‐Jun Quan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-04-18
卷期号:26 (17): 3575-3580
标识
DOI:10.1021/acs.orglett.4c00993
摘要
We introduce switchable chemoselectivity strategies based on the hydrazone phosphaketene intermediate to synthesize three classes of 1,2,4-diazaphosphol derivatives. First, the five-membered heterocyclic P and O anion intermediates acted as nucleophilic agents in the selective construction of C–P and C–O bonds. Second, the phosphinidene served as a phosphorus synthon, allowing for the formation of C–P and C–N bonds. Finally, a stepwise mechanism, supported by DFT calculations, was invoked to explain the reaction selectivity.
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