Sugarcane Stem Derived Hybrid Scaffold for Bone Tissue Engineering via Top-down Approach

脚手架 材料科学 生物相容性 组织工程 多孔性 纤维素 化学工程 生物医学工程 复合材料 工程类 医学 冶金
作者
Shi Jiawei,Xuemeng Bai,Yahui Zheng,Jianfei Che,Yinghong Xiao
出处
期刊:Composite Interfaces [Taylor & Francis]
卷期号:30 (3): 323-340 被引量:4
标识
DOI:10.1080/09276440.2022.2111773
摘要

A novel bone tissue engineering material with a merit of good biocompatibility and excellent mechanical properties was fabricated with a top-down method. In this work, sugarcane was first treated in NaClO2/acetate buffer to remove lignin, i.e. delignification, and the effect of delignification on pore size of sugarcane is explored bby varying the soaking time in the buffer. Results show that 4 h is the optimal delignification time to ensure good mechanical properties of the sugarcane. The subsequent surface modification with alendronate trihydrate has an advantage to facilitate the final deposition of hydroxyapatite (HAp) due to the fact that the introduction of phosphate groups can effectively improve the nucleation efficiency of HAp. We found that the deposited HAp on sugarcane stem templates can form a bioactive hybrid scaffold material with a hierachical pore structure. Fortunately, during the delignification process of the cellulose structure in the sugarcane stem is not destroyed, thus the hierarchical pore structure remains. The final obtained hybrid scaffold presents a three-dimensional anisotropic porous structure and its longitudinal strength is much higher than the radial strength. The anisotropic property can provide a good mechanical support for scaffold applications. Moreover, the CCK-8 test shows that the cell viability is higher than 95%, indicating that the scaffold exhibits no cytotoxicity. Our investigation demonstrates that the presented hybrid scaffold derived from sugarcane stem has a great potential in the application of bone tissue engineering.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
kk发布了新的文献求助10
刚刚
自觉竺完成签到,获得积分10
1秒前
1秒前
mjj完成签到,获得积分10
1秒前
Kay发布了新的文献求助10
2秒前
乖猫要努力应助debuffv采纳,获得10
2秒前
2秒前
美好斓发布了新的文献求助10
3秒前
搜集达人应助pipi1412采纳,获得10
3秒前
4秒前
4秒前
meng发布了新的文献求助10
4秒前
研友_VZG7GZ应助魅雪霓采纳,获得10
5秒前
斯文明杰发布了新的文献求助10
5秒前
江峰驳回了张雷应助
6秒前
Orange应助mjj采纳,获得10
6秒前
7秒前
winter发布了新的文献求助20
7秒前
NexusExplorer应助超靓诺言采纳,获得10
8秒前
monica发布了新的文献求助10
8秒前
8秒前
斯文败类应助eff采纳,获得10
8秒前
Ava应助humblelucas采纳,获得10
9秒前
Avert.完成签到 ,获得积分10
9秒前
ding应助Mila采纳,获得10
10秒前
DijiaXu应助chong0919采纳,获得10
10秒前
飞天走地的香辣鱿鱼完成签到,获得积分10
10秒前
北鱼完成签到 ,获得积分10
10秒前
Kay完成签到,获得积分10
10秒前
南宫子骞完成签到,获得积分10
10秒前
11秒前
11秒前
汪汪队路马完成签到,获得积分10
11秒前
11秒前
13秒前
meng完成签到,获得积分10
13秒前
大模型应助生动的翠容采纳,获得30
14秒前
bkagyin应助李昕123采纳,获得10
15秒前
凉笙墨染完成签到,获得积分10
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971277
求助须知:如何正确求助?哪些是违规求助? 3515939
关于积分的说明 11180280
捐赠科研通 3251061
什么是DOI,文献DOI怎么找? 1795664
邀请新用户注册赠送积分活动 875937
科研通“疑难数据库(出版商)”最低求助积分说明 805209