脂肪组织
脂毒性
肥胖
串扰
炎症
高脂血症
海西定
内分泌学
医学
内科学
生物
糖尿病
能量稳态
生物信息学
胰岛素抵抗
物理
光学
作者
Gina Cavaliere,Fabiano Cimmino,Giovanna Trinchese,Angela Catapano,Lidia Petrella,Margherita D’Angelo,Lucio Lucchin,Maria Pina Mollica
出处
期刊:Antioxidants
[MDPI AG]
日期:2023-05-29
卷期号:12 (6): 1172-1172
被引量:20
标识
DOI:10.3390/antiox12061172
摘要
Obesity is a major risk factor for several metabolic diseases, including type 2 diabetes, hyperlipidemia, cardiovascular diseases, and brain disorders. Growing evidence suggests the importance of inter-organ metabolic communication for the progression of obesity and the subsequent onset of related disorders. This review provides a broad overview of the pathophysiological processes that from adipose tissue dysfunction leading to altered multi-tissue crosstalk relevant to regulating energy homeostasis and the etiology of obesity. First, a comprehensive description of the role of adipose tissue was reported. Then, attention was turned toward the unhealthy expansion of adipose tissue, low-grade inflammatory state, metabolic inflexibility, and mitochondrial dysfunction as root causes of systemic metabolic alterations. In addition, a short spot was devoted to iron deficiency in obese conditions and the role of the hepcidin–ferroportin relationship in the management of this issue. Finally, different classes of bioactive food components were described with a perspective to enhance their potential preventive and therapeutic use against obesity-related diseases.
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