Personalized medicine in colorectal cancer: a comprehensive study of precision diagnosis and treatment

医学 个性化医疗 精密医学 结直肠癌 癌症 内科学 肿瘤科 生物信息学 医学物理学 病理 生物
作者
Fatemeh Gila,Somayeh Khoddam,Zahra Jamali,Majid Ghasemian,Shayan Shakeri,Zeinab Dehghan,Jafar Fallahi
出处
期刊:Personalized Medicine [Future Medicine]
卷期号:: 1-23
标识
DOI:10.1080/17410541.2025.2459050
摘要

Colorectal cancer is a common and fatal disease that affects many people globally. CRC is classified as the third most prevalent cancer among males and the second most frequent cancer among females worldwide. The purpose of this article is to examine how personalized medicine might be used to treat colorectal cancer. The classification of colorectal cancer based on molecular profiling, including the detection of significant gene mutations, genomic instability, and gene dysregulation, is the main topic of this discussion. Advanced technologies and biomarkers are among the detection methods that are explored, demonstrating their potential for early diagnosis and precise prognosis. In addition, the essay explores the world of treatment possibilities by providing light on FDA-approved personalized medicine solutions that provide individualized and precise interventions based on patient characteristics. This article assesses targeted treatments like cetuximab and nivolumab, looks at the therapeutic usefulness of biomarkers like microsatellite instability (MSI) and circulating tumor DNA (ctDNA), and investigates new approaches to combat resistance. Through this, our review provides a thorough overview of personalized medicine in the context of colorectal cancer, ultimately highlighting its potential to revolutionize the field and improve patient care.

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