伤口愈合
伤口敷料
沸石咪唑盐骨架
化学
咪唑酯
生物医学工程
材料科学
医学
外科
有机化学
金属有机骨架
吸附
复合材料
作者
Zhao Chen,Man Zhe,Wenting Wu,Peiyun Yu,Yuzhen Xiao,Lei Zhu,Ming Liu,Zhou Xiang,Fei Xing
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2024-11-10
卷期号:16 (11): 1429-1429
标识
DOI:10.3390/pharmaceutics16111429
摘要
Background: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection. Methods: In this research, we created an injectable hydrogel wound dressing formulated from gelatin methacryloyl (GelMA) that encapsulates quercetin-loaded zeolitic imidazolate framework-8 (Qu@ZIF-8) nanoparticles. Next, its ability to promote skin wound healing was validated through in vitro experiments and animal studies. Results: Research conducted both in vitro and in vivo indicated that this hydrogel dressing effectively mitigates inflammation, inhibits bacterial growth, and promotes angiogenesis and collagen synthesis, thus facilitating a safe and efficient healing process for wounds. Conclusions: This cutting-edge scaffold system provides a novel strategy for wound repair and demonstrates significant potential for clinical applications.
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