RNA剪接
选择性拼接
肝癌
生物
计算生物学
信使核糖核酸
癌症
生物信息学
核糖核酸
基因
遗传学
作者
Qi Jia,Xiaoxiao Sun,Haoyu Li,Jianglong Guo,Kongyan Niu,Kui Ming Chan,René Bernards,Wenxin Qin,Haojie Jin
出处
期刊:Gut
[BMJ]
日期:2024-12-10
卷期号:: gutjnl-333127
标识
DOI:10.1136/gutjnl-2024-333127
摘要
Perturbation of mRNA splicing is commonly observed in human cancers and plays a role in various aspects of cancer hallmarks. Understanding the mechanisms and functions of alternative splicing (AS) not only enables us to explore the complex regulatory network involved in tumour initiation and progression but also reveals potential for RNA-based cancer treatment strategies. This review provides a comprehensive summary of the significance of AS in liver cancer, covering the regulatory mechanisms, cancer-related AS events, abnormal splicing regulators, as well as the interplay between AS and post-transcriptional and post-translational regulations. We present the current bioinformatic approaches and databases to detect and analyse AS in cancer, and discuss the implications and perspectives of AS in the treatment of liver cancer.
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