材料科学
自愈水凝胶
恶唑啉
韧性
丙烯酸
复合材料
粘弹性
聚合
化学工程
高分子化学
聚合物
有机化学
共聚物
催化作用
工程类
化学
作者
Paola A. Benitez‐Duif,Marina Breisch,Daniel Kurka,Karlina Edel,Semra Gökcay,Dominic Stangier,W. Tillmann,Montasser Hijazi,Joerg C. Tiller
标识
DOI:10.1002/adfm.202204837
摘要
Abstract The exceptional stiffness and toughness of double‐network hydrogels (DNHs) offer the possibility to mimic even complex biomaterials, such as cartilage. The latter has a limited regenerative capacity and thus needs to be substituted with an artificial material. DNHs composed of cross‐linked poly(2‐oxazoline)s (POx) and poly(acrylic acid) (PAA) are synthesized by free radical polymerization in a two‐step process. The resulting DNHs are stabilized by hydrogen bridges even at pH 7.4 (physiological PBS buffer) due to the pK a ‐shifting effect of POx on PAA. DNHs based on poly(2‐methyl‐2‐oxazoline), which have a water content (WC) of around 66 wt% and are not cytotoxic, show biomechanical properties that match those of cartilage in terms of WC, stiffness, toughness, coefficient of friction, compression in body relevant stress conditions and viscoelastic behavior. This material also has high strength in PBS pH 7.4 and in egg white as synovial liquid substitute. In particular, a compression strength of up to 60 MPa makes this material superior.
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