壳聚糖
溶解度
药物输送
傅里叶变换红外光谱
纳米颗粒
核化学
化学
毒品携带者
溶解
结合
材料科学
化学工程
有机化学
纳米技术
工程类
数学分析
数学
作者
Stavroula Nanaki,Konstantinos Spyrou,Pelagia Veneti,Niki Karouta,Dimitrios Gournis,Turki N. Baroud,Panagiotis Barmpalexis,Dimitrios Ν. Bikiaris
出处
期刊:Polymers
[MDPI AG]
日期:2022-09-24
卷期号:14 (19): 4004-4004
被引量:6
标识
DOI:10.3390/polym14194004
摘要
The present study evaluates the use of thiolized chitosan conjugates (CS) in combination with two fundamental carbon nanoforms (carbon dots (CDs) and Hierarchical Porous Carbons (HPC)) for the preparation of intranasally (IN) administrated galantamine (GAL) nanoparticles (NPs). Initially, the modification of CS with L-cysteine (Cys) was performed, and the successful formation of a Cys-CS conjugates was verified via 1H-NMR, FTIR, and pXRD. The new Cys-CS conjugate showed a significant solubility enhancement in neutral and alkaline pH, improving CS’s utility as a matrix-carrier for IN drug administration. In a further step, drug-loaded NPs were prepared via solid-oil–water double emulsification, and thoroughly analyzed by SEM, DLS, FTIR and pXRD. The results showed the formation of spherical NPs with a smooth surface, while the drug was amorphously dispersed within most of the prepared NPs, with the exemption of those systems contianing the CDs. Finally, in vitro dissolution release studies revealed that the prepared NPs could prolong GAL’s release for up to 12 days. In sum, regarding the most promising system, the results of the present study clearly suggest that the preparation of NPs using both Cys-CS and CDs results in a more thermodynamically stable drug dispersion, while a zero-order release profile was achieved, which is essential to attain a stable in vivo pharmacokinetic behavior.
科研通智能强力驱动
Strongly Powered by AbleSci AI