细胞毒性T细胞
抗原呈递
表位
抗原
MHC I级
生物
主要组织相容性复合体
抗原处理
表观遗传学
细胞生物学
交叉展示
免疫学
遗传学
基因
体外
作者
Ruth Soler-Agesta,Alberto Anel,Lorenzo Galluzzi
出处
期刊:Cancer Cell
[Elsevier]
日期:2023-10-26
卷期号:41 (11): 1849-1851
被引量:1
标识
DOI:10.1016/j.ccell.2023.10.001
摘要
Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.
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