Prediction of the survival of patients with advanced‐stage ovarian cancer patients undergoing interval cytoreduction with the use of computed tomography reevaluation after neoadjuvant chemotherapy

医学 比例危险模型 卵巢癌 单变量分析 危险系数 阶段(地层学) 化疗 生存分析 回顾性队列研究 放射科 多元分析 肿瘤科 癌症 外科 内科学 置信区间 古生物学 生物
作者
Jia‐Yi Li,Rui Wang
出处
期刊:Journal of Obstetrics and Gynaecology Research [Wiley]
卷期号:49 (11): 2700-2710 被引量:1
标识
DOI:10.1111/jog.15760
摘要

To predict ovarian cancer patients' survival by computed tomography (CT) reevaluation after neoadjuvant chemotherapy.In this retrospective single-center cohort study, all patients with advanced epithelial ovarian cancer underwent platinum-based chemotherapy followed by interval cytoreductive surgery. Assessment of abdominal and pelvic lesions before and after chemotherapy using CT scoring criteria. Meanwhile, the progression-free survival and overall survival times were obtained. The Kaplan-Meier method was used to estimate survival curves. Univariate analysis of continuous and categorical variables was performed for prognostic significance using the Cox proportional hazards model. Variables with p < 0.10 on univariate analysis were then included in a multivariate forward stepwise Cox regression analysis.A total of 162 patients were included, with a median age of 52 years (range, 20-72 years). One hundred seven patients (66.0%) underwent suboptimal cytoreduction, and there was no statistically significant difference in patient survival between surgical procedures (log-rank p = 0.092). Six radiographic features were hazard factors for suboptimal cytoreduction. Four features in the postchemotherapy CT images were assigned as predictive criteria by the stepwise regression model (area under the curve [AUC] = 0.689). As compared with a higher AUC (0.713) in the model involving two clinical variables (age and postsurgery CA-125) and two postchemotherapy CT features, the model considering the CT score changes before and after chemotherapy had the highest diagnostic accuracy (AUC = 0.843).CT reevaluation after neoadjuvant chemotherapy is essential for ovarian cancer, the changes of CT feature and score are potential great tools to predict patient survival.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
279完成签到,获得积分10
刚刚
1秒前
小程同学完成签到,获得积分10
1秒前
曹牧之完成签到 ,获得积分10
1秒前
2秒前
balabalabala发布了新的文献求助10
2秒前
迷人觅云关注了科研通微信公众号
2秒前
3秒前
smottom应助呆萌代桃采纳,获得10
3秒前
4秒前
4秒前
怂怂的哈哈怪完成签到,获得积分20
4秒前
sss发布了新的文献求助10
4秒前
5秒前
花花完成签到 ,获得积分10
5秒前
深情安青应助谨慎秋珊采纳,获得10
5秒前
LamChem完成签到,获得积分10
6秒前
Giner发布了新的文献求助10
6秒前
Doudou完成签到,获得积分10
6秒前
量子星尘发布了新的文献求助10
6秒前
Delight完成签到 ,获得积分10
6秒前
luyjabc发布了新的文献求助10
7秒前
7秒前
英俊的铭应助研友_LNVX1L采纳,获得30
7秒前
7秒前
ZH发布了新的文献求助10
7秒前
完美世界应助Baneyhua采纳,获得10
7秒前
8秒前
xiaohu6311发布了新的文献求助10
8秒前
8秒前
syhjxk发布了新的文献求助10
9秒前
彭于彦祖应助REBACK采纳,获得30
9秒前
bronny发布了新的文献求助10
10秒前
10秒前
11秒前
sx发布了新的文献求助10
11秒前
11秒前
11秒前
飞飞发布了新的文献求助10
12秒前
丘比特应助郑文涛采纳,获得10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969335
求助须知:如何正确求助?哪些是违规求助? 3514162
关于积分的说明 11172430
捐赠科研通 3249456
什么是DOI,文献DOI怎么找? 1794853
邀请新用户注册赠送积分活动 875437
科研通“疑难数据库(出版商)”最低求助积分说明 804809