自噬
细胞生物学
内质网
再生(生物学)
生物
内皮干细胞
祖细胞
细胞内
粒体自噬
诱导多能干细胞
未折叠蛋白反应
胚胎干细胞
干细胞
生物化学
细胞凋亡
基因
体外
作者
Basheer Abdullah Marzoog
出处
期刊:Current Aging Science
[Bentham Science]
日期:2024-03-01
卷期号:17 (1): 58-67
标识
DOI:10.2174/0118746098260689231002044435
摘要
Autophagy plays a crucial role in maintaining endothelial cell homeostasis through the turnover of intracellular components during stress conditions in a lysosomal-dependent manner. The regeneration strategy involves several aspects, including autophagy. Autophagy is a catabolic degenerative lysosomal-dependent degradation of intracellular components. Autophagy modifies cellular and subcellular endothelial cell functions, including mitochondria stress, lysosomal stress, and endoplasmic reticulum unfolded protein response. Activation of common signaling pathways of autophagy and regeneration and enhancement of intracellular endothelial cell metabolism serve as the bases for the induction of endothelial regeneration. Endothelial progenitor cells include induced pluripotent stem cells (iPSC), embryonic stem cells, and somatic cells, such as fibroblasts. Future strategies of endothelial cell regeneration involve the induction of autophagy to minimize the metabolic degeneration of the endothelial cells and optimize the regeneration outcomes.
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