作者
Silvia Mariani,I‐Wen Wang,Bas C.T. van Bussel,Samuel Heuts,Dominik Wiedemann,Diyar Saeed,Iwan C.C. van der Horst,Mattéo Pozzi,Antonio Loforte,Udo Boeken,Robertas Samalavičius,Karl Bounader,Xiaotong Hou,Jeroen J.H. Bunge,Hergen Buscher,Leonardo Salazar,Bart Meyns,Daniel Herr,Sacha Matteucci,Sandro Sponga,Kollengode Ramanathan,Claudio Russo,Francesco Formica,Pranya Sakiyalak,Antonio Fiore,Daniele Camboni,Giuseppe Maria Raffa,Rodrigo Díaz,Jae‐Seung Jung,Jan Bělohlávek,Vin Pellegrino,Giacomo Bianchi,Matteo Pettinari,Alessandro Barbone,José Pérez García,Kiran Shekar,Glenn Whitman,Roberto Lorusso,Justine M. Ravaux,Anne‐Kristin Schaefer,Luca Conci,Philipp Szalkiewicz,Khalil Jawad,Sven Lehmann,Jean-François Obadia,Nikolaos Kalampokas,Erwan Flécher,Dinís Dos Reis Miranda,Kogulan Sriranjan,Michael A. Mazzeffi,Nazli Vedadi,Marco Di Eusanio,Graeme MacLaren,Vitaly Sorokin,Alessandro Costetti,Çhristof Schmid,Roberto Castillo,Vladimír Mikulenka,Marco Solinas
摘要
Abstract
Objectives
Postcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare patient characteristics as well as in-hospital and long-term survival between intraoperative and postoperative ECMO. Methods
The retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1) study includes adults who required ECMO due to postcardiotomy shock between 2000 and 2020. We compared patients who received ECMO in the operating theater (intraoperative) with those in the intensive care unit (postoperative) on in-hospital and postdischarge outcomes. Results
We studied 2003 patients (women: 41.1%; median age: 65 years; interquartile range [IQR], 55.0-72.0). Intraoperative ECMO patients (n = 1287) compared with postoperative ECMO patients (n = 716) had worse preoperative risk profiles. Cardiogenic shock (45.3%), right ventricular failure (15.9%), and cardiac arrest (14.3%) were the main indications for postoperative ECMO initiation, with cannulation occurring after (median) 1 day (IQR, 1-3 days). Compared with intraoperative application, patients who received postoperative ECMO showed more complications, cardiac reoperations (intraoperative: 19.7%; postoperative: 24.8%, P = .011), percutaneous coronary interventions (intraoperative: 1.8%; postoperative: 3.6%, P = .026), and had greater in-hospital mortality (intraoperative: 57.5%; postoperative: 64.5%, P = .002). Among hospital survivors, ECMO duration was shorter after intraoperative ECMO (median, 104; IQR, 67.8-164.2 hours) compared with postoperative ECMO (median, 139.7; IQR, 95.8-192 hours, P < .001), whereas postdischarge long-term survival was similar between the 2 groups (P = .86). Conclusions
Intraoperative and postoperative ECMO implantations are associated with different patient characteristics and outcomes, with greater complications and in-hospital mortality after postoperative ECMO. Strategies to identify the optimal location and timing of postcardiotomy ECMO in relation to specific patient characteristics are warranted to optimize in-hospital outcomes.