A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization

梗阻性肥厚性心肌病 隔脊髓切除术 肥厚性心肌病 梗阻性心肌病 计算机科学 心脏病学 医学 动力学(音乐) 心肌病 内科学 物理 心力衰竭 声学
作者
Zhihao Ding,Qianwen Liu,Huan Luo,Ming Yang,Yining Zhang,Shilin Wang,Yuanming Luo,Shu Chen
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:14 (1)
标识
DOI:10.1038/s41598-024-74091-3
摘要

Although septal myectomy is the preferred treatment for medication-refractory hypertrophic obstructive cardiomyopathy (HOCM), the procedure remains subjective. A preoperative planning procedure is proposed using computational fluid dynamics simulations and shape optimization to assist in the objective assessment of the adequacy of the resection. 3 patients with HOCM were chosen for the application of the proposed procedure. The geometries of the preoperative left ventricular outflow tract (LVOT) of patients in the systolic phase were reconstructed from medical images. Computaional fluid dynamics (CFD) simulations were performed to assess hemodynamics within LVOT. Sensitivity analysis was performed to determine the resection extent on the septal wall, and the depth of the resection was optimized to relieve LVOT obstruction while minimizing damage to the septum. The optimized resection was then transferred from systole to diastole to provide surgeons with instructive guidance for septal myectomy. Comparison between preoperative and postoperative hemodynamics showed an evident improvement with respect to the pressure gradient throughout the LVOT. The resected myocardium in the diastolic phase is more extended and thinner than its state in the systolic phase. The proposed preoperative planning procedure may be a viable addition to the current preoperative assessment of patients with HOCM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小希完成签到,获得积分10
1秒前
1秒前
隐形曼青应助阿九采纳,获得10
2秒前
深情安青应助杨玄采纳,获得10
2秒前
简化为完成签到,获得积分10
2秒前
J_C_Van完成签到,获得积分10
3秒前
橘子树完成签到,获得积分10
4秒前
玛斯特尔完成签到,获得积分10
4秒前
hearz发布了新的文献求助10
4秒前
ZSH完成签到,获得积分10
5秒前
Litoivda完成签到 ,获得积分10
7秒前
暮雨完成签到,获得积分10
8秒前
DOGDAD完成签到,获得积分10
10秒前
英俊的铭应助温柔翰采纳,获得10
10秒前
英姑应助薛建伟采纳,获得10
10秒前
如云完成签到,获得积分20
11秒前
你说的完成签到 ,获得积分10
11秒前
Jasper应助大脸猫4811采纳,获得10
12秒前
hearz完成签到,获得积分10
13秒前
14秒前
P2JY完成签到,获得积分10
14秒前
leiiiiiiii完成签到,获得积分10
14秒前
Bake完成签到 ,获得积分10
16秒前
17秒前
yuan完成签到,获得积分10
17秒前
论文多多完成签到,获得积分10
18秒前
18秒前
Acid完成签到 ,获得积分10
18秒前
1111111111111发布了新的文献求助10
19秒前
linlinyilulvdeng完成签到,获得积分10
19秒前
斯文败类应助历史雨采纳,获得10
20秒前
FashionBoy应助吃个大笼包采纳,获得10
22秒前
海阔天空发布了新的文献求助10
23秒前
薛建伟发布了新的文献求助10
24秒前
高高代珊发布了新的文献求助10
25秒前
害羞的墨镜完成签到,获得积分10
25秒前
lalala发布了新的文献求助10
25秒前
26秒前
guojingjing完成签到,获得积分10
26秒前
打打应助科多兽骑士采纳,获得10
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038657
求助须知:如何正确求助?哪些是违规求助? 3576306
关于积分的说明 11375198
捐赠科研通 3306108
什么是DOI,文献DOI怎么找? 1819379
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066