A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization

梗阻性肥厚性心肌病 隔脊髓切除术 肥厚性心肌病 梗阻性心肌病 计算机科学 心脏病学 医学 动力学(音乐) 心肌病 内科学 物理 心力衰竭 声学
作者
Zhihao Ding,Qianwen Liu,Huan Luo,Ming Yang,Yining Zhang,Shilin Wang,Yuanming Luo,Shu Chen
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:14 (1)
标识
DOI:10.1038/s41598-024-74091-3
摘要

Although septal myectomy is the preferred treatment for medication-refractory hypertrophic obstructive cardiomyopathy (HOCM), the procedure remains subjective. A preoperative planning procedure is proposed using computational fluid dynamics simulations and shape optimization to assist in the objective assessment of the adequacy of the resection. 3 patients with HOCM were chosen for the application of the proposed procedure. The geometries of the preoperative left ventricular outflow tract (LVOT) of patients in the systolic phase were reconstructed from medical images. Computaional fluid dynamics (CFD) simulations were performed to assess hemodynamics within LVOT. Sensitivity analysis was performed to determine the resection extent on the septal wall, and the depth of the resection was optimized to relieve LVOT obstruction while minimizing damage to the septum. The optimized resection was then transferred from systole to diastole to provide surgeons with instructive guidance for septal myectomy. Comparison between preoperative and postoperative hemodynamics showed an evident improvement with respect to the pressure gradient throughout the LVOT. The resected myocardium in the diastolic phase is more extended and thinner than its state in the systolic phase. The proposed preoperative planning procedure may be a viable addition to the current preoperative assessment of patients with HOCM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
我爱科研完成签到,获得积分10
1秒前
2秒前
碰碰完成签到,获得积分10
2秒前
2秒前
大个应助Aaron采纳,获得10
2秒前
Carrot完成签到,获得积分10
3秒前
英俊的铭应助宫冷雁采纳,获得10
3秒前
汉堡包应助zzy采纳,获得30
5秒前
5秒前
路灯下的小伙完成签到,获得积分10
5秒前
ning发布了新的文献求助10
5秒前
欢呼吐司发布了新的文献求助20
8秒前
十一发布了新的文献求助10
8秒前
大模型应助shinn采纳,获得50
8秒前
9秒前
11秒前
onlyan发布了新的文献求助10
12秒前
13秒前
14秒前
14秒前
16秒前
16秒前
ning完成签到,获得积分10
16秒前
万能图书馆应助西瓜籽采纳,获得10
17秒前
18秒前
18秒前
18秒前
宫冷雁发布了新的文献求助10
19秒前
sqz完成签到,获得积分10
19秒前
20秒前
20秒前
21秒前
21秒前
Mickey完成签到,获得积分10
21秒前
慕青应助enen采纳,获得30
21秒前
九卫发布了新的文献求助10
21秒前
23秒前
天天快乐应助二十六画生采纳,获得10
23秒前
维维完成签到 ,获得积分10
24秒前
24秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975250
求助须知:如何正确求助?哪些是违规求助? 3519625
关于积分的说明 11199055
捐赠科研通 3255962
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877358
科研通“疑难数据库(出版商)”最低求助积分说明 806298