巨噬细胞移动抑制因子
免疫系统
抑制性突触后电位
巨噬细胞
癌症研究
免疫学
生物
神经科学
细胞因子
体外
生物化学
作者
Xiaoqing Xie,Yaxian Liu,Jun-Ke Wang,Lixia Lu,Jaewoo Hong,Jiayu Chen,Yang Yang
出处
期刊:PubMed
日期:2024-06-01
卷期号:40 (6): 561-565
摘要
Macrophage migration inhibitor factor (MIF), as a pro-inflammatory and oncogenic cytokine, is highly expressed in a variety of malignant tumors and recruits tumor cells or immune cells into the tumor microenvironment. MIF affects the development of tumor by altering the tumor microenvironment. In the process of tumor, MIF not only plays an anti-inflammatory role, but also promotes tumorigenesis by immune escape and immune tolerance.This is closely related to immune cells that play a role in the tumor immune response, mainly including natural killer (NK) cells, macrophages, dendritic cells, B cells, T cells and myeloid-derived suppressor cells. The article summarizes the role of MIF in tumor immune and the relationship between MIF and the development of malignant tumors, in order to provide new ideas and possible therapy for tumor treatment.
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