微泡
伤口愈合
干细胞
慢性伤口
线粒体
细胞生物学
生物医学工程
干细胞疗法
材料科学
医学
纳米技术
化学
生物
小RNA
免疫学
生物化学
基因
作者
Wende Yao,Junnian Zhou,Chao Tang,Julei Zhang,Zhaoyang Chen,Yan Li,Xiaojing Gong,Mingyi Qu,Quan Zeng,Yi Jia,Haiyang Wang,Tao Fan,Jing Ren,Lingli Guo,Jiafei Xi,Xuetao Pei,Yan Han,Wen Yue
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-09-05
标识
DOI:10.1021/acsnano.4c06921
摘要
Rescuing or compensating mitochondrial function represents a promising therapeutic avenue for radiation-induced chronic wounds. Adult stem cell efficacies are primarily dependent on the paracrine secretion of mitochondria-containing extracellular vesicles (EVs). However, effective therapeutic strategies addressing the quantity of mitochondria and mitochondria-delivery system are lacking. Thus, in this study, we aimed to design an effective hydrogel microneedle patch (MNP) loaded with stem cell-derived mitochondria-rich EVs to gradually release and deliver mitochondria into the wound tissues and boost wound healing. We, first, used metformin to enhance mitochondrial biogenesis and thereby increasing the secretion of mitochondria-containing EVs (termed "Met-EVs") in adipose-derived stem cells. To verify the therapeutic effects of Met-EVs, we established an
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