作者
Andrew Octavian Sasmita,Constanze Depp,T. I. Nazarenko,Ting Sun,Sophie B Siems,Erinne Cherisse Ong,Yakum Bertrand Nkeh,Carolin Böhler,Xuan Yu,Bastian Bues,Lorelie Evangelista,Shuying Mao,Bárbara Morgado,Z. Wu,Torben Ruhwedel,Swati Subramanian,Friederike Börensen,Katharina Overhoff,Lena Spieth,Stefan A. Berghoff,Katherine R. Sadleir,Robert Vassar,Simone Eggert,Sandra Goebbels,Takashi Saito,Takaomi C. Saido,Gesine Saher,Wiebke Möbius,Gonçalo Castelo‐Branco,Hans‐Wolfgang Klafki,Oliver Wirths,Jens Wiltfang,Sarah Jäkel,Riqiang Yan,Klaus‐Armin Nave
摘要
Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APP