Chelation in metal intoxication

Ability of some structurally different chelating agents to mobilize manganese from liver and testis of rats pretreated with manganese sulphate for 25 days, was evaluated. Attempts were made to draw a parallel between removal of the metal and recovery of the altered biochemical and pathological parameters in early manganese poisoning. Though all the compounds were able to remove manganese significantly from the two organs, a definite relationship was exhibited by nitrilotriacetic acid, diethylenetriaminepentaacetic acid and p-aminosalicylic acid.