立体中心
对映选择合成
亲电胺化
化学
电泳剂
催化作用
胺化
钪
分子间力
有机化学
组合化学
立体化学
分子
作者
Jiang Nan,Jingjing Liu,Huayu Zheng,Zhijun Zuo,Lei Hou,Huai‐Ming Hu,Yao‐Yu Wang,Xinjun Luan
标识
DOI:10.1002/anie.201409565
摘要
Abstract Catalytic asymmetric aminative dearomatization of 1‐substituted 2‐naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral Sc III /pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective CN bond‐forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen‐containing quaternary carbon stereocenters.
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