止血
生物相容性
化学
生物相容性材料
骨愈合
自愈水凝胶
自组装肽
再生(生物学)
生物医学工程
外科
医学
细胞生物学
高分子化学
有机化学
生物
作者
Min Wu,Zhaoyang Ye,Hongyan Zhu,Xiao‐Jun Zhao
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2015-09-08
卷期号:16 (10): 3112-3118
被引量:43
标识
DOI:10.1021/acs.biomac.5b00493
摘要
The use of local agents to achieve hemostasis of bone that does not interfere with repair and recovery is a complex and emergency subject in surgery. In this study, the dual functional biodegradable self-assembling nanopeptide (SAP) RADA16-I was synthesized by solid phase synthesis and was shown to exhibit immediate hemostasis and accelerative osteosis. The RADA16-I showed good performance as a hemostatic agent, which was investigated by comparison with the effects of bone wax in the ilium bone defect model of New Zealand rabbits. The RADA16-I exhibited efficient function of bone regeneration in both radiographic analysis and histological examination, while the bone wax inhibited osteogenesis. Moreover, in in vivo experiment, the RADA16-I was shown to exhibit excellent biocompatibility, while the group with bone wax showed a severe inflammatory response at the interface with bone. Thus, the RADA16-I is proven to be an excellent biocompatible material with effective dual function of hemostasis and osteosis.
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