Protein-tyrosine phosphorylation: an essential component of FcεRI signaling

Mast cell and basophil activation can be achieved by antigen-mediated aggregation of cell surface FcεRI molecules. At least two signaling pathways are triggered by this activation. Both involve tyrosine phosphorylation. This aspect of FcεRI signaling is examined here in detail and its position in a complex network of post-binding events assessed.