Therapy of human B-cell lymphoma bearing scid mice is more effective with anti-CD19-and anti-CD38-saporin immunotoxins used in combination than with either immunotoxin used alone

免疫毒素 皂甙 医学 淋巴瘤 抗体 免疫学 CD38 单克隆抗体 CD19 药理学 内科学 生物 干细胞 川地34 遗传学
作者
David J. Flavell,Deborah A. Boehm,Loretta Emery,Armorel Moss,Alan G. Ramsay,Sopsamorn U. Flavell
出处
期刊:International Journal of Cancer [Wiley]
卷期号:62 (3): 337-344 被引量:34
标识
DOI:10.1002/ijc.2910620318
摘要

Abstract The CD 19 + CD38 + human Burkitt's lymphoma cell line Ramos grows aggressively when injected intravenously (i.v.) into severe combined immunodeficient (SCID) mice, killing 100% of animals within a 33–42 day period with widely disseminated disease. Treatment commencing 7 days after i.v. injection of Ramos cells, with 3 doses of an anti‐CD 19 immunotoxin (IT; BU12‐SAPORIN) or an anti‐CD38 IT (OKTIO‐SAPORIN) led to a significant prolongation of survival compared with shamtreated controls; the anti‐CD38 IT gave the greatest prolongation of survival, but all treated animals eventually succumbed to disease. When both ITs were used in combination at equivalent dose levels, the therapeutic outcome was significantly improved over that obtained for single IT therapy, with 20% of animals surviving disease‐free to 300 days. When anti‐CD38 IT was given in combination with anti‐CD 19 antibody there was no therapeutic improvement over anti‐CD38 IT used alone. However, when anti‐CD 19 IT was given in combination with CD38 antibody, a significant prolongation of survival ensued over that obtained with anti‐CD 19 IT alone, though this was not as significantly pronounced as that obtained when both ITs were used in combination and was only as good as the survival obtained with OKT10 antibody used alone. CD 19 and CD38 are expressed on the surface of the vast majority of B‐cell lymphoma and common acute lymphoblastic leukaemia cells, and our findings provide a sound rationale for a combination immunotoxin trial in these diseases directed against both these target molecules. © 1995 Wiley‐Liss Inc.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
七七完成签到 ,获得积分10
2秒前
2秒前
帅哥完成签到 ,获得积分10
4秒前
李李李发布了新的文献求助10
6秒前
gayfall完成签到,获得积分10
6秒前
6秒前
西城暖阳发布了新的文献求助10
7秒前
FHY发布了新的文献求助10
7秒前
8秒前
李健应助123采纳,获得10
9秒前
妮妮完成签到,获得积分10
10秒前
Akim应助linginging采纳,获得10
11秒前
xunmacaoyan完成签到,获得积分10
11秒前
11秒前
lzh发布了新的文献求助20
12秒前
14秒前
bkagyin应助能HJY采纳,获得10
14秒前
YY发布了新的文献求助10
15秒前
上官若男应助李李李采纳,获得10
16秒前
悦耳蜡烛完成签到,获得积分10
17秒前
小绿茶完成签到 ,获得积分10
18秒前
18秒前
123发布了新的文献求助10
19秒前
小篆完成签到 ,获得积分10
19秒前
21秒前
FLOR发布了新的文献求助10
26秒前
田様应助king采纳,获得10
27秒前
27秒前
清森发布了新的文献求助10
28秒前
修辞完成签到,获得积分10
29秒前
略略完成签到,获得积分10
30秒前
a1oft发布了新的文献求助10
32秒前
32秒前
FLOR完成签到,获得积分10
35秒前
36秒前
卷卷完成签到,获得积分10
36秒前
37秒前
xshlzwyyh完成签到,获得积分10
37秒前
赘婿应助酷酷夏天采纳,获得10
39秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256273
求助须知:如何正确求助?哪些是违规求助? 2898535
关于积分的说明 8301409
捐赠科研通 2567721
什么是DOI,文献DOI怎么找? 1394646
科研通“疑难数据库(出版商)”最低求助积分说明 652913
邀请新用户注册赠送积分活动 630557